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Posts tagged worms

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C. elegans
A simple way to study the nervous system is by looking at small worms, C. elegans.  They have a very specific number of neurons (302) and a consistent pattern of how they connect and where they are located.  They have a “brain” (term used loosely) which is a collection of nerves in their head- a ganglia is just a term for a bunch of nerves grouped together.  We have ganglia too- for instance the doral root ganglia, which is a bunch of sensory neurons along the spinal cord.
Anyway, why do we care about C. elegans?  Well, the simplicity of their nervous system (302 total neurons as compared to our ~100 billions neurons) means that it is much easier to look at and identify specific neurons.  They are an ideal model for neuronal development and neurodegeneration/neurogenesis.  You can see what types of genes, for example, might disrupt the normal development of their nervous system.  You can also sever a single neuron and see what it needs to grow back to where it was.  This is a much smaller scale injury as compared to human spinal cord injury, but it may help develop treatments that could be used to treat human developmental disorders or spinal cord injuries.
[Image Source]

C. elegans

A simple way to study the nervous system is by looking at small worms, C. elegans.  They have a very specific number of neurons (302) and a consistent pattern of how they connect and where they are located.  They have a “brain” (term used loosely) which is a collection of nerves in their head- a ganglia is just a term for a bunch of nerves grouped together.  We have ganglia too- for instance the doral root ganglia, which is a bunch of sensory neurons along the spinal cord.

Anyway, why do we care about C. elegans?  Well, the simplicity of their nervous system (302 total neurons as compared to our ~100 billions neurons) means that it is much easier to look at and identify specific neurons.  They are an ideal model for neuronal development and neurodegeneration/neurogenesis.  You can see what types of genes, for example, might disrupt the normal development of their nervous system.  You can also sever a single neuron and see what it needs to grow back to where it was.  This is a much smaller scale injury as compared to human spinal cord injury, but it may help develop treatments that could be used to treat human developmental disorders or spinal cord injuries.

[Image Source]

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